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X-ray diffraction
2.5Å resolution

Structure of Human ATP:Cobalamin adenosyltransferase bound to ATP.

Released:
DOI: 10.2210/pdb2idx/pdb
PDB entry 2idx coloured by chain, front view.
PDB entry 2idx coloured by chain, side view.
PDB entry 2idx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of ATP-bound human ATP:cobalamin adenosyltransferase.
Schubert HL, Hill CP
Biochemistry 45 15188-96 (2006)
PMID: 17176040

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188481 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Corrinoid adenosyltransferase MMAB Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 196 amino acids
Theoretical weight: 21.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96EY8 (Residues: 56-250; Coverage: 78%)
Gene name: MMAB
Sequence domains: Cobalamin adenosyltransferase
Structure domains: Cobalamin adenosyltransferase-like

Ligands and Environments

4 bound ligands:
Ligand SO4 3 x SO4
Ligand CL 1 x CL
Ligand MG 4 x MG
Ligand ATP 2 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: P3121
Unit cell:
a: 111.238Å b: 111.238Å c: 115.526Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.197 0.251
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The tinker, tailor, soldier in intracellular B12 trafficking.
Banerjee et al. (2009)
5 more

11 mentions without citation

Structure of ATP-bound human ATP:cobalamin adenosyltransferase.
Schubert et al. (2006)
10 more