› 2y23

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE MYOMESIN DOMAINS MY9-MY11

Released:
DOI: 10.2210/pdb2y23/pdb
PDB entry 2y23 coloured by chain, front view.
PDB entry 2y23 coloured by chain, side view.
PDB entry 2y23 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties.
Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M
PLoS Biol 10 e1001261 (2012)
PMID: 22347812

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myomesin-1 Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 36.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52179 (Residues: 1141-1447; Coverage: 18%)
Gene name: MYOM1
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand BME 3 x BME
Ligand PG0 1 x PG0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P21
Unit cell:
a: 61.471Å b: 41.487Å c: 84.862Å
α: 90° β: 88.39° γ: 90°
R-values:
R R work R free
0.211 0.209 0.271
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

The sarcomeric cytoskeleton: from molecules to motion.
Gautel et al. (2016)
5 more

5 mentions without citation

The sarcomeric M-region: a molecular command center for diverse cellular processes.
Hu et al. (2015)
4 more