3kyc

X-ray diffraction
2.45Å resolution

Human SUMO E1 complex with a SUMO1-AMP mimic

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-159021 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
SUMO-activating enzyme subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBE0 (Residues: 1-346; Coverage: 100%)
Gene names: AOS1, SAE1, SUA1, UBLE1A
Sequence domains: ThiF family
Structure domains: NAD(P)-binding Rossmann-like Domain
SUMO-activating enzyme subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 660 amino acids
Theoretical weight: 73.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBT2 (Residues: 1-640; Coverage: 100%)
Gene names: HRIHFB2115, SAE2, UBA2, UBLE1B
Sequence domains:
Structure domains:
Small ubiquitin-related modifier 1 Chain: D
Molecule details ›
Chain: D
Length: 97 amino acids
Theoretical weight: 11.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63165 (Residues: 1-97; Coverage: 96%)
Gene names: OK/SW-cl.43, SMT3C, SMT3H3, SUMO1, UBL1
Sequence domains: Ubiquitin-2 like Rad60 SUMO-like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 59.174Å b: 133.365Å c: 159.656Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.25
Expression system: Escherichia coli