› 3l0r

X-ray diffraction
2.45Å resolution

Crystal Structure of Salivary Cystatin from the Soft Tick Ornithodoros moubata

Released:
DOI: 10.2210/pdb3l0r/pdb
PDB entry 3l0r coloured by chain, front view.
PDB entry 3l0r coloured by chain, side view.
PDB entry 3l0r coloured by chain, top view.
Source organism: Ornithodoros moubata
Primary publication:
Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata.
Salát J, Paesen GC, Rezácová P, Kotsyfakis M, Kovárová Z, Sanda M, Majtán J, Grunclová L, Horká H, Andersen JF, Brynda J, Horn M, Nunn MA, Kopácek P, Kopecký J, Mares M
Biochem J 429 103-12 (2010)
PMID: 20545626

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystatin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 115 amino acids
Theoretical weight: 13.08 KDa
Source organism: Ornithodoros moubata
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6QD55 (Residues: 20-128; Coverage: 100%)
Sequence domains: Cystatin domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P3121
Unit cell:
a: 69.805Å b: 69.805Å c: 133.994Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.188 0.223
Expression system: Spodoptera frugiperda

Quick links

Citations

15 review citations

Implication of haematophagous arthropod salivary proteins in host-vector interactions.
Fontaine et al. (2011)
14 more

6 mentions without citation

Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata.
Salát et al. (2010)
5 more