› 3s4r

X-ray diffraction
2.45Å resolution

Crystal structure of vimentin coil1A/1B fragment with a stabilizing mutation

Released:
DOI: 10.2210/pdb3s4r/pdb
PDB entry 3s4r coloured by chain, front view.
PDB entry 3s4r coloured by chain, side view.
PDB entry 3s4r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structure of the vimentin central α-helical domain and its implications for intermediate filament assembly.
Chernyatina AA, Nicolet S, Aebi U, Herrmann H, Strelkov SV
Proc Natl Acad Sci U S A 109 13620-5 (2012)
PMID: 22869704

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vimentin Chains: A, B
Molecule details ›
Chains: A, B
Length: 93 amino acids
Theoretical weight: 11.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08670 (Residues: 99-189; Coverage: 20%)
Gene name: VIM

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: R32
Unit cell:
a: 65.329Å b: 65.329Å c: 377.339Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.293 0.292 0.315
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Intermediate Filaments: Structure and Assembly.
Herrmann et al. (2016)
18 more

9 mentions without citation

Restrictive Cardiomyopathy is Caused by a Novel Homozygous Desmin (DES) Mutation p.Y122H Leading to a Severe Filament Assembly Defect.
Brodehl et al. (2019)
8 more