Function and Biology Details
Reaction catalysed:
(1a) cholesterol + 2 reduced adrenodoxin + O(2) + 2 H(+) = (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H(2)O
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138503 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cholesterol side-chain cleavage enzyme, mitochondrial
Molecule details ›
Chains: A, B
Length: 487 amino acids
Theoretical weight: 56.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450
Length: 487 amino acids
Theoretical weight: 56.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P05108 (Residues: 41-521; Coverage: 92%)
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450
Adrenodoxin, mitochondrial
Molecule details ›
Chains: C, D
Length: 114 amino acids
Theoretical weight: 12.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: 2Fe-2S iron-sulfur cluster binding domain
Structure domains: Ubiquitin-like (UB roll)
Length: 114 amino acids
Theoretical weight: 12.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P10109 (Residues: 62-175; Coverage: 62%)
Sequence domains: 2Fe-2S iron-sulfur cluster binding domain
Structure domains: Ubiquitin-like (UB roll)
