› 4dkc

X-ray diffraction
1.85Å resolution

Crystal Structure of Human Interleukin-34

Released:
DOI: 10.2210/pdb4dkc/pdb
PDB entry 4dkc coloured by chain, front view.
PDB entry 4dkc coloured by chain, side view.
PDB entry 4dkc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
Ma X, Lin WY, Chen Y, Stawicki S, Mukhyala K, Wu Y, Martin F, Bazan JF, Starovasnik MA
Structure 20 676-87 (2012)
PMID: 22483114

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Interleukin-34 Chains: A, B
Molecule details ›
Chains: A, B
Length: 190 amino acids
Theoretical weight: 21.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6ZMJ4 (Residues: 21-193; Coverage: 78%)
Gene names: C16orf77, IL34
Sequence domains: Interleukin 34
Structure domains: Interleukin-34

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 57.694Å b: 77.866Å c: 58.083Å
α: 90° β: 103.25° γ: 90°
R-values:
R R work R free
0.175 0.174 0.203
Expression system: Trichoplusia ni

Quick links

Citations

39 review citations

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation.
Italiani et al. (2014)
38 more

4 mentions without citation

Finding the needle in the haystack: towards solving the protein-folding problem computationally.
Li et al. (2018)
3 more