› 4wv4

X-ray diffraction
1.91Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171458 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcription initiation factor TFIID subunit 10 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 11.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12962 (Residues: 112-212; Coverage: 46%)
Gene names: TAF10, TAF2A, TAF2H, TAFII30
Sequence domains: Transcription initiation factor TFIID 23-30kDa subunit
Transcription initiation factor TFIID subunit 8 Chain: B
Molecule details ›
Chain: B
Length: 97 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7Z7C8 (Residues: 25-120; Coverage: 31%)
Gene names: TAF8, TAFII43, TBN
Sequence domains: Bromodomain associated
Structure domains: Histone, subunit A

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P3121
Unit cell:
a: 51.32Å b: 51.32Å c: 144.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.205 0.237
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

Structure and mechanism of the RNA polymerase II transcription machinery.
Schier et al. (2020)
8 more

2 mentions without citation

Zooming in on Transcription Preinitiation.
Gupta et al. (2016)
1 more