Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8t12
Q-score: 0.422
To Be Published
- Non-structural protein 5 (103 kDa, Protein from Dengue virus type 2)
- Signal transducer and activator of transcription 2 (98 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Complex of denv2 ns5 and huamn stat2 (Complex from Homo sapiens)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8t13
Q-score: 0.416
To Be Published
- Signal transducer and activator of transcription 2 (98 kDa, Protein from Homo sapiens)
- Non-structural protein 5 (103 kDa, Protein from Dengue virus type 2)
- Complex of denv2 ns5 with human stat2 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
CryoEM structure of isNS1 in complex with Fab56.2 and HDL
Chew BLA, Ngoh AQ, Phoo WW, Chan KWK, Ser Z, Tulsian NK, Lim SS, Weng MJG, Watanabe S, Choy MM, Low JG, Ooi EE, Ruedl C, Sobota RM, Vasudevan SG, Luo D
eLife (2023) [ DOI: doi:10.7554/eLife.90762.1 ]
- Fab 56.2 heavy chain (Macromolecule from Mus musculus)
- Core protein (Macromolecule from Dengue virus type 2)
- Ternary complex of fab56.2 with dengue virus nonstructural protein 1 and high density lipoprotein (Complex)
- Isns1ts (Complex from Dengue virus type 2)
- Monoclonal antibody fragment 56.2 (Complex from Mus musculus)
- Fab 56.2 light chain (Macromolecule from Mus musculus)
CryoEM structure of isNS1 in complex with Fab56.2
Chew BLA, Ngoh AQ, Phoo WW, Chan KWK, Ser Z, Tulsian NK, Lim SS, Weng MJG, Watanabe S, Choy MM, Low JG, Ooi EE, Ruedl C, Sobota RM, Vasudevan SG, Luo D
eLife (2023) [ DOI: doi:10.7554/eLife.90762.1 ]
- Fab56.2 heavy chain (Macromolecule from Mus musculus)
- Fab56.2 light chain (Macromolecule from Mus musculus)
- Ternary complex of fab56.2 with dengue virus nonstructural protein 1 and high density lipoprotein (Complex)
- Core protein (Macromolecule from dengue virus type 2)
- Isns1ts (Complex from Dengue virus type 2)
- Fab56.2 (Complex from Mus musculus)
Adeno-associated virus type 2 VLP displaying M2 peptide
Cuevas-Juarez E, Linan-Torres A, Hernandez C, Kopylov M, Potter CS, Carragher B, Ramirez OT, Palomares LA
Biotechnol Bioeng (2023) 120 pp. 2658-2671 [ DOI: doi:10.1002/bit.28392 Pubmed: 37058415 ]
Adeno-associated virus type 2 VLP displaying Linker peptide
Cuevas-Juarez E, Linan-Torres A, Hernandez C, Kopylov M, Potter CS, Carragher B, Ramirez OT, Palomares LA
Biotechnol Bioeng (2023) 120 pp. 2658-2671 [ DOI: doi:10.1002/bit.28392 Pubmed: 37058415 ]
Cryo-EM structure of the NS5-SLA complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8gzp
Q-score: 0.486
Osawa T, Aoki M, Ehara H, Sekine SI
Mol Cell (2023) 83 pp. 2781- [ Pubmed: 37478848 DOI: doi:10.1016/j.molcel.2023.06.023 ]
- Genome polyprotein (104 kDa, Protein from Dengue virus)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Rna (54 kDa, RNA from synthetic construct)
- Rna replicase complex bound to the mini-genome rna (Complex from Dengue virus)
- Magnesium ion (24 Da, Ligand)
- Mini-genome rna (Complex from synthetic construct)
- Ns5 (Complex from Dengue virus)
Cryo-EM structure of the NS5-NS3-SLA complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8gzq
Q-score: 0.429
Osawa T, Aoki M, Ehara H, Sekine SI
Mol Cell (2023) 83 pp. 2781- [ Pubmed: 37478848 DOI: doi:10.1016/j.molcel.2023.06.023 ]
- Genome polyprotein (104 kDa, Protein from Dengue virus)
- Ns3 (Complex from Dengue virus)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Rna (54 kDa, RNA from synthetic construct)
- Rna replicase complex bound to the mini-genome rna (Complex from Dengue virus)
- Mini-genome rna (Complex from synthetic construct)
- Genome polyprotein (74 kDa, Protein from Dengue virus)
- Ns5 (Complex from Dengue virus)
Cryo-EM structure of the the NS5-NS3 RNA-elongation complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8gzr
Q-score: 0.638
Osawa T, Aoki M, Ehara H, Sekine SI
Mol Cell (2023) 83 pp. 2781- [ Pubmed: 37478848 DOI: doi:10.1016/j.molcel.2023.06.023 ]
- Genome polyprotein (104 kDa, Protein from Dengue virus)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Ns3 (Complex from Dengue virus)
- Zinc ion (65 Da, Ligand)
- Rna (12 kDa, RNA from synthetic construct)
- Cytidine-5'-diphosphate (403 Da, Ligand)
- Rna (Complex from synthetic construct)
- Manganese (ii) ion (54 Da, Ligand)
- Genome polyprotein (74 kDa, Protein from Dengue virus)
- Ns5-ns3 rna-elongation complex (Complex from Dengue virus)
- Ns5 (Complex from Dengue virus)
Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody
Resolution: 10.2 Å
EM Method: Single-particle
Fitted PDBs: 8fe3
Q-score: 0.059
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ DOI: doi:10.1073/pnas.2218899120 Pubmed: 36638211 ]
- Prm12 fab heavy chain (24 kDa, Protein from Mus musculus)
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
- Prm12 fab light chain (23 kDa, Protein from Mus musculus)