Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ DOI: doi:10.1038/s41541-024-00862-8 Pubmed: 38582771 ]
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines (cH125 TTT)
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ DOI: doi:10.1038/s41541-024-00862-8 Pubmed: 38582771 ]
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines (H2/1 GCN4)
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ DOI: doi:10.1038/s41541-024-00862-8 Pubmed: 38582771 ]
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines (H5/1 GCN4)
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ DOI: doi:10.1038/s41541-024-00862-8 Pubmed: 38582771 ]
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines. H5 GCN4
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ DOI: doi:10.1038/s41541-024-00862-8 Pubmed: 38582771 ]
In-situ structure of the hexameric HEF trimers from influenza C viral particles
To Be Published
- Haemagglutinin-esterase-fusion 2 glycoprotein (Protein from Influenza C virus (C/Johannesburg/1/66))
- Haemagglutinin-esterase-fusion 1 glycoprotein (Protein from Influenza C virus (C/Johannesburg/1/66))
- Influenza c virus (c/johannesburg/1/66) (1 MDa, Virus from Influenza C virus (C/Johannesburg/1/66))
Resolution: 6.67 Å
EM Method: Single-particle
Fitted PDBs: 8izn
Q-score: 0.124
To Be Published
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8v7o
Q-score: 0.453
Nagashima KA, Dzimianski JV, Yang M, Abendroth J, Sautto G, Ross TM, DuBois RM, Edwards TE, Mousa JJ
To Be Published
- Hemagglutinin (62 kDa, Protein from Influenza A virus)
- #58 light chain (11 kDa, Protein from Homo sapiens)
- Complex of cobra ha x6 with #58 fab (Complex from Homo sapiens)
- #58 heavy chain (14 kDa, Protein from Homo sapiens)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8r60
Q-score: 0.406
Keown JR, Carrique L, Fodor E, Grimes JM
To Be Published
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 h1n1 influenza virus heterotrimer in complex with a 4 repeat serine 5 phosphorylated peptide from polii ctd (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2 (102 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna polymerase ii 4 repeat peptide with serine5 phosphorylation (3 kDa, Protein from Homo sapiens)
Resolution: 4.23 Å
EM Method: Single-particle
Fitted PDBs: 8r65
Q-score: 0.18
Keown JR, Carrique L, Fodor E, Grimes JM
To Be Published
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 h1n1 viral polymerase heterotrimer in complex with 4 repeat serine-5 phosphorylated polii peptide with ordered pb2 c-terminal domains (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2 (102 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna polymerase ii 4 repeat peptide with serine5 phosphorylation (3 kDa, Protein from Homo sapiens)