Resolution: 7.0 Å
EM Method: Single-particle
Fitted PDBs: 8v0y
Q-score: 0.15
Risi CM, Belknap B, Atherton J, Coscarella IL, White HD, Bryant Chase P, Pinto JR, Galkin VE
J Mol Biol (2024) 436 pp. 168498-168498 [ Pubmed: 38387550 DOI: doi:10.1016/j.jmb.2024.168498 ]
- Troponin c, slow skeletal and cardiac muscles (18 kDa, Protein from Sus scrofa)
- Tropomyosin alpha-1 chain (32 kDa, Protein from Sus scrofa)
- Troponin t2, cardiac type (33 kDa, Protein from Sus scrofa)
- Troponin i, cardiac muscle (24 kDa, Protein from Sus scrofa)
- Actin, alpha cardiac muscle 1 (42 kDa, Protein from Sus scrofa)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Thin filament troponin core complex (Complex from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of Myosin VI in the autoinhibited state (without SAH-extension density)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8w41
Q-score: 0.34
Niu F, Li L, Wang L, Xiao J, Xu S, Liu Y, Lin L, Yu C, Wei Z
Nat Commun (2024) 15 pp. 1187- [ DOI: doi:10.1038/s41467-024-45424-7 ]
- Complex of myosin vi and calmodulin (Complex)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Unconventional myosin-vi (148 kDa, Protein from Homo sapiens)
- Myosin vi (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Calmodulin (Complex from Mus musculus)
- Phosphate ion (94 Da, Ligand)
Cryo-EM map of Myosin VI in the autoinhibited state (with SAH-extension density)
Niu F, Li L, Wang L, Xiao J, Xu S, Liu Y, Lin L, Yu C, Wei Z
Nat Commun (2024) 15 pp. 1187- [ DOI: doi:10.1038/s41467-024-45424-7 ]
- Complex of myosin vi and calmodulin (Complex)
- Myosin vi (Protein from Homo sapiens)
- Myosin vi (Complex from Homo sapiens)
- Calmodulin (Complex from Mus musculus)
- Calmodulin (Protein from Mus musculus)
In situ human cardiac thick filament in the relaxed state
Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA
PNAS (2024) 121 pp. e2311883121-e2311883121 [ DOI: doi:10.1073/pnas.2311883121 Pubmed: 38386705 ]
Human cardiac interacting heads motif (IHM-C) in complete form
Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA
PNAS (2024) 121 pp. e2311883121-e2311883121 [ DOI: doi:10.1073/pnas.2311883121 Pubmed: 38386705 ]
Human cardiac interacting heads motif (IHM-C) in semi form
Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA
PNAS (2024) 121 pp. e2311883121-e2311883121 [ DOI: doi:10.1073/pnas.2311883121 Pubmed: 38386705 ]
Human cardiac interacting heads motif (IHM-S)
Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA
PNAS (2024) 121 pp. e2311883121-e2311883121 [ DOI: doi:10.1073/pnas.2311883121 Pubmed: 38386705 ]
Human cardiac interacting heads motif (IHM-D) in semi form
Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA
PNAS (2024) 121 pp. e2311883121-e2311883121 [ DOI: doi:10.1073/pnas.2311883121 Pubmed: 38386705 ]
Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8rbx
Q-score: 0.037
Fianu I, Ochmann M, Walshe JL, Dybkov O, Cruz JN, Urlaub H, Cramer P
Nature (2024) [ Pubmed: 38570683 DOI: doi:10.1038/s41586-024-07269-4 ]
- Integrator complex subunit 4 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 7 (107 kDa, Protein from Homo sapiens)
- Template dna (56 kDa, DNA from synthetic construct)
- Negative elongation factor c/d (65 kDa, Protein from Homo sapiens)
- Rna polymerase ii subunit k (7 kDa, Protein from Sus scrofa)
- Integrator complex subunit 1 (244 kDa, Protein from Homo sapiens)
- Integrator complex subunit 15 (50 kDa, Protein from Homo sapiens)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Nelf-b,negative elongation factor b,negative elongation factor b,negative elongation factor b,negative elongation factor b,negative elongation factor b (68 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Integrator complex subunit 6 (100 kDa, Protein from Homo sapiens)
- Non-template dna (45 kDa, DNA from synthetic construct)
- Dsif (Complex from Trichoplusia ni)
- Unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk-unk (1 kDa, Protein from Homo sapiens)
- Integrator complex subunit 13 (80 kDa, Protein from Homo sapiens)
- Integrator complex subunit 14 (57 kDa, Protein from Homo sapiens)
- Transcription elongation factor spt5 (121 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Sus scrofa)
- Integrator-pp2a complex and nelf (Complex from Homo sapiens)
- Histone h2b type 1-j (13 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase subunit beta (134 kDa, Protein from Sus scrofa)
- Pre-termination complex (1 MDa, Complex)
- Manganese (ii) ion (54 Da, Ligand)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Dss1 (3 kDa, Protein from Trichoplusia ni)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb11-a (13 kDa, Protein from Sus scrofa)
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Rna polymerase ii subunit d (16 kDa, Protein from Sus scrofa)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from Sus scrofa)
- Rna and dna (Complex from Sus scrofa)
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit e (24 kDa, Protein from Sus scrofa)
- Integrator complex subunit 2 (134 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase subunit (217 kDa, Protein from Sus scrofa)
- Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from Sus scrofa)
- Negative elongation factor a (57 kDa, Protein from Homo sapiens)
- Unk-unk-unk-unk-unk-unk-unk-unk (698 Da, Protein from Sus scrofa)
- Dna-directed rna polymerase ii (Complex from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from Sus scrofa)
- Rna (5 kDa, RNA from synthetic construct)
- Histone h2a type 1 (14 kDa, Protein from Homo sapiens)
- Nucleosome (Complex from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Sus scrofa)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Sus scrofa)
- Histone h3.3c (15 kDa, Protein from Homo sapiens)
Structure of Integrator-PP2A-SOSS-CTD post-termination complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8rbz
Q-score: 0.293
Fianu I, Ochmann M, Walshe JL, Dybkov O, Cruz JN, Urlaub H, Cramer P
Nature (2024) [ Pubmed: 38570683 DOI: doi:10.1038/s41586-024-07269-4 ]
- Integrator complex subunit 4 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 7 (107 kDa, Protein from Homo sapiens)
- Dss1 (Complex from Trichoplusia ni)
- Integrator complex subunit 1 (244 kDa, Protein from Homo sapiens)
- Rna polymerase ii c-terminal domain peptides (Complex from Sus scrofa)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 15 (50 kDa, Protein from Homo sapiens)
- Integrator complex subunit 6 (100 kDa, Protein from Homo sapiens)
- Unk-unk-unk-unk-unk-unk-unk-unk-unk (783 Da, Protein from Sus scrofa)
- Integrator complex subunit 14 (57 kDa, Protein from Homo sapiens)
- Integrator complex subunit 13 (80 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Post-termination complex (1 MDa, Complex)
- Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
- Dss1 (3 kDa, Protein from Trichoplusia ni)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Soss complex subunit c (11 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase subunit (1 kDa, Protein from Sus scrofa)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Integrator complex subunit 3 (118 kDa, Protein from Homo sapiens)
- Soss complex subunit b1 (22 kDa, Protein from Homo sapiens)
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Integrator complex subunit 2 (134 kDa, Protein from Homo sapiens)
- Integrator-pp2a complex and nabp2 and inip (Complex from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)