› 4cc8

Electron Microscopy
6Å resolution

Pre-fusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

Released:
DOI: 10.2210/pdb4cc8/pdb
PDB entry 4cc8 coloured by chain, front view.
PDB entry 4cc8 coloured by chain, side view.
PDB entry 4cc8 coloured by chain, top view.
Source organisms:
Primary publication:
Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy.
Bartesaghi A, Merk A, Borgnia MJ, Milne JL, Subramaniam S
Nat Struct Mol Biol 20 1352-7 (2013)
PMID: 24154805
Related structures: EMD-2484

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-211648 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
GP41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 31 amino acids
Theoretical weight: 2.66 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
GP120 Chains: D, E, G
Molecule details ›
Chains: D, E, G
Length: 344 amino acids
Theoretical weight: 29.29 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
MONOCLONAL ANTIBODY VRC03 FAB HEAVY CHAIN Chains: F, H, I
Molecule details ›
Chains: F, H, I
Length: 233 amino acids
Theoretical weight: 25.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
MONOCLONAL ANTIBODY VRC03 FAB LIGHT CHAIN Chains: J, K, L
Molecule details ›
Chains: J, K, L
Length: 209 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6Å
Relevant EMDB volumes: EMD-2484
Expression system: Homo sapiens

Quick links

Citations

23 review citations

Structural insights on the role of antibodies in HIV-1 vaccine and therapy.
West et al. (2014)
22 more

2 mentions without citation

Morphology and ultrastructure of retrovirus particles.
Zhang et al. (2015)
1 more